Hydrochloric Acid → HCID 10493689, compound

HRID 2395196Notes

Reaction equation

HRID 2395196 reaction equation
C(O[CH:4](OCC)[CH2:5][NH:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][CH2:17][C:18]([F:23])([F:22])[CH:19]([F:21])[F:20])=[CH:12][CH:11]=1)=[O:8])C.Cl>CO.O>[F:23][C:18]([F:22])([CH:19]([F:20])[F:21])[CH2:17][O:16][C:13]1[CH:12]=[CH:11][C:10]([N:9]2[CH:4]=[CH:5][NH:6][C:7]2=[O:8])=[CH:15][CH:14]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 10643600HCID 10643600, compound

Product 1

HCID 10493689HCID 10493689, compoundYield 80.1%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

N-(2,2-Diethoxyethyl)-N'-[4-(2,2,3,3-tetrafluoropropoxy)phenyl] urea (37.5 g) was dissolved in a mixture of 560 ml of methanol and 280 ml of water. To the solution was added 300 ml of an aqueous solution containing 0.48M of hydrochloric acid and the mixture was stirred at room temperature for 3 days. The reaction mixture was concentrated under reduced pressure and the precipitated crystals were washed with a mixture of water-methanol (5:1) to give 22.8 g of 1-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-2-(1H,3H)-imidazolone as colorless powder.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. washthe precipitated crystals were washed with a mixture of water-methanol (5:1)

Sources & evidence

ORD record
ord-5e06cc5b14164de1885b35c3e3fddded
Source dataset
uspto-grants-1998_09
Patent number
US05814324

Reaction notes

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