反应详情

To 1-isobutylpiperazine dihydrochloride(69.5 g) was added 10% aqueous solution of sodium hydrochloride(100 ml) and the mixture was extracted with ether. After being concentrated, the extract was distilled under a vacuum(bp 172°-174° C./5 mmHg), thereby yielding 43.7 g of 1-isobutylpiperazine.

1. extractionthe mixture was extracted with ether
2. concentrationAfter being concentrated
3. distillationthe extract was distilled under a vacuum(bp 172°-174° C./5 mmHg)