1-Isobutylpiperazine dihydrochloride → 1-(2-Methylpropyl)piperazine

HRID 2395248Notes

Reaction equation

HRID 2395248 reaction equation
Cl.Cl.[CH2:3]([N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)[CH:4]([CH3:6])[CH3:5]>Cl.[Na]>[CH2:3]([N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)[CH:4]([CH3:6])[CH3:5]

Participants

3

Reactant 1

HCID 27593881-Isobutylpiperazine dihydrochloride

Product 1

HCID 20520521-(2-Methylpropyl)piperazineYield 95.1%

Reagents, catalysts & solvents 1

HCID 23872008Sodium hydrochlorideSolvent

Procedure

To 1-isobutylpiperazine dihydrochloride(69.5 g) was added 10% aqueous solution of sodium hydrochloride(100 ml) and the mixture was extracted with ether. After being concentrated, the extract was distilled under a vacuum(bp 172°-174° C./5 mmHg), thereby yielding 43.7 g of 1-isobutylpiperazine.

Workup

  1. extractionthe mixture was extracted with ether
  2. concentrationAfter being concentrated
  3. distillationthe extract was distilled under a vacuum(bp 172°-174° C./5 mmHg)

Sources & evidence

ORD record
ord-189a9b11a9ba4088b4d9ca7c9289457b
Source dataset
uspto-grants-1998_09
Patent number
US05814634

Reaction notes

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