2-Amino-3-methylbenzoic acid → HCID 18971521, compound

HRID 2395271Notes

Reaction equation

HRID 2395271 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]=[C:12]=[O:13])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH2:14][C:15]1[C:23]([CH3:24])=[CH:22][CH:21]=[CH:20][C:16]=1[C:17](O)=[O:18]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([N:11]2[C:17](=[O:18])[C:16]3[C:15](=[C:23]([CH3:24])[CH:22]=[CH:21][CH:20]=3)[NH:14][C:12]2=[O:13])(=[O:9])=[O:10])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 781012-Amino-3-methylbenzoic acidHCID 1385874-Chlorobenzenesulfonyl isocyanate

Product 1

HCID 18971521HCID 18971521, compoundYield 98%

Procedure

2.00 g (9.19 mmol) of 4-chlorobenzenesulfonylisocyanate and 1.26 g (8.33 mmol) of 2-amino-3-methylbenzoic acid were treated in the same way as in Example 1 to obtain 2.86 g of the above-identified compound (yield 98.0%). Properties: colorless crystal, Melting point: 221°-225° C., PMR (δppm, DMSO-d6): 2.32 (3H,s), 7.12 (1H,t), 7.51 (1H,d), 7.72 (1H,d), 7.76 (2H,d), 8.19 (2H,d), 11.10 (1H,br).

Sources & evidence

ORD record
ord-62a0382aff674906bea536b903c25ea4
Source dataset
uspto-grants-1998_09
Patent number
US05814631

Reaction notes

Loading…