HRID2395335

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID520026

4-Chloro-3-(trifluoromethyl)phenyl isothiocyanate

C8H3ClF3NS

结构：O=[N+]([O-])c1ccc(Sc2nc3ccccc3[nH]2)cc1

HCID12617625

2-[(4-Nitrophenyl)sulfanyl]-1H-benzimidazole

C13H9N3O2S

PRODUCTS

生成物

结构：FC(F)(F)c1cc(NC(=S)Nc2ccc(Sc3nc4ccccc4[nH]3)cc2)ccc1Cl

HCID53736644

未命名化合物

收率 5%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

2-(4-Nitrophenylthio)benzimidazole (5.0 mmoles, 1.37 g) was reduced in ethyl acetate over 1.37 g 5% Pd/C, filtered and condensed and then reacted with 4-chloro-3-trifluoromethylphenylisothiocyanate (5.0 mmoles, 1.0 g) according to procedure C to yield the title compound 0.12 g, 5% product. Mass Spec (FD) 479. Calculated for C21H14ClF3N4 S2 : C, 52.66; H, 2.95; N, 11.70. Found: C, 52.85; H, 3.18; N, 10.47.

WORKUP

后处理

filtrationfiltered
customcondensed