1-Chloro-4-isothiocyanato-2-(trifluoromethyl)benzene → 1-[4-(6-Phenyl-3-pyridazylthio)phenyl]-3-(4-chloro-3-trifluoromethylphenyl)thiourea

HRID 2395352Notes

Reaction equation

HRID 2395352 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[N:10]=[N:11][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:13][CH:14]=2)=[CH:4][CH:3]=1.[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([N:28]=[C:29]=[S:30])=[CH:24][C:23]=1[C:31]([F:34])([F:33])[F:32]>>[C:15]1([C:12]2[N:11]=[N:10][C:9]([S:8][C:5]3[CH:4]=[CH:3][C:2]([NH:1][C:29]([NH:28][C:25]4[CH:26]=[CH:27][C:22]([Cl:21])=[C:23]([C:31]([F:34])([F:32])[F:33])[CH:24]=4)=[S:30])=[CH:7][CH:6]=3)=[CH:14][CH:13]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 5200261-Chloro-4-isothiocyanato-2-(trifluoromethyl)benzeneHCID 189716613-(4-Aminophenylthio)-6-phenylpyridazine

Product 1

HCID 189716821-[4-(6-Phenyl-3-pyridazylthio)phenyl]-3-(4-chloro-3-trifluoromethylphenyl)thioureaYield 69.1%

Procedure

3-(4-aminophenylthio)-6-phenylpyridazine (7.0 mmoles, 2.0 g) and 4-chloro-3-trifluoromethylphenylisothiocyanate (7.0 mmoles, 1.66 g) were reacted according to procedure C to yield of the title compound 2.5 g, 69%. Mass Spec (FD) 516. Calculated for C24H16ClF3 N4O2S2 : C, 55.76; H, 3.12; N, 10.84. Found: C, 55.98 H, 3.19; N, 10.78.

Sources & evidence

ORD record
ord-972c0db6ff35466b9ed9810581237fa1
Source dataset
uspto-grants-1998_09
Patent number
US05814646

Reaction notes

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