2-(3-benzyloxyphenyl)-4,5-dihydro-4(R)-phenyloxazole → (R)-3-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol

Participants

Role	Name	HCID	Charge
Reactant	2-(3-benzyloxyphenyl)-4,5-dihydro-4(R)-phenyloxazole	HCID 18665552	—
Catalyst	Palladium	HCID 23938	—
Solvent	Ethyl Acetate	HCID 8857	—
Product	(R)-3-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol	HCID 18665562	48.4%

Reaction Steps

2-(3-Benzyloxyphenyl)-4,5-dihydro-4(R)-phenyloxazole (3 g, 8.9 mmol) was dissolved in ethyl acetate (15 ml) and hydrogenolyzed in the presence of 10% palladium-on-charcoal (300 mg). Recrystallization from ethyl acetate/n-hexane gave 4,5-dihydro-2-(3-hydroxyphenyl)-4(R)-phenyloxazole (1.03 g, 48% ) as colorless needles.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05814648
Source dataset	uspto-grants-1998_09
ORD ID	ord-62991a0a54d641febc5c977efbd66948
Source note	uspto-grants-1998_09