Chloroacetaldehyde → HCID 18971828, compound

HRID 2395411Notes

Reaction equation

HRID 2395411 reaction equation
[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH:13]=[CH:14][C:15]=2[O:16][CH3:17])[C:10](=[S:12])[NH2:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[CH2:19][CH:20]=O>C(O)C>[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([C:10]3[S:12][CH:19]=[CH:20][N:11]=3)[CH:13]=[CH:14][C:15]=2[O:16][CH3:17])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 33ChloroacetaldehydeHCID 18971770HCID 18971770, compound

Product 1

HCID 18971828HCID 18971828, compoundYield 63.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 130 mg of 3-cyclopentyloxy-4-methoxybenzthioamide and 100 mg of chloroacetaldehyde in 15 ml of ethanol was heated at reflux for 6 hours. The volatiles were evaporated and the residue purified on silica gel with CH2Cl2 to give 90 mg of product. M.P.: 72°-75° C.

Workup

  1. temperatureat reflux for 6 hours
  2. customThe volatiles were evaporated
  3. customthe residue purified on silica gel with CH2Cl2

Sources & evidence

ORD record
ord-dbc5468491db4b0e9cf0ec5b8f20af6c
Source dataset
uspto-grants-1998_09
Patent number
US05814651

Reaction notes

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