Dimethylformamide dimethyl acetal → HCID 53811492, compound

HRID 2395550Notes

Reaction equation

HRID 2395550 reaction equation
[CH:1]1([C:4](=[O:19])[CH2:5][C:6]([C:8]2[C:16]3[O:15][C:14]([F:18])([F:17])[O:13][C:12]=3[CH:11]=[CH:10][CH:9]=2)=[O:7])[CH2:3][CH2:2]1.CO[CH:22](OC)[N:23]([CH3:25])[CH3:24]>C1(C)C=CC=CC=1>[CH:1]1([C:4](=[O:19])[C:5](=[CH:22][N:23]([CH3:25])[CH3:24])[C:6]([C:8]2[C:16]3[O:15][C:14]([F:18])([F:17])[O:13][C:12]=3[CH:11]=[CH:10][CH:9]=2)=[O:7])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 18989146HCID 18989146, compound

Product 1

HCID 53811492HCID 53811492, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 4-(3-cyclopropyl-1,3-dioxoprop-1-yl)-2,2-difluoro-1,3-benzodioxole (12.0 g) in dry toluene was treated with N,N-dimethylformamide dimethyl acetal and the mixture stirred overnight. After evaporation in vacuo and re-evaporation after addition of toluene the residue was recrystal from cyclohexane-ethanol to give 4-(3-cyclopropyl-2-dimethylaminomethylene-1,3-dioxopropyl)-2,2-difluoro-1,3-benzodioxole (6.5 g) as a pale yellow solid, m.p. 118°-119° C.

Workup

  1. customAfter evaporation
  2. customin vacuo and re-evaporation
  3. additionafter addition of toluene the residue

Sources & evidence

ORD record
ord-1d4a3d853da94f1684b18edf85e660d7
Source dataset
uspto-grants-1996_02
Patent number
US05489570

Reaction notes

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