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Dimethylformamide → 2,2-Difluoro-1,3-benzodioxole-4-carbonyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 2,2-Difluoro-1,3-dioxaindane-4-carboxylic acid | HCID 2774067 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 生成物 | 2,2-Difluoro-1,3-benzodioxole-4-carbonyl chloride | HCID 2774062 | 106% |
反応手順
2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid (15.0 g) was dissolved in 1,2-dichloroethane and N,N-dimethylformamide and thionyl chloride (10.6 g) added. The mixture was heated under reflux for 1 hour, and the solvent evaporated in vacuo. The residue was dissolved in toluene and re-evaporated to yield 2,2-difluoro-1,3-benzodioxol-4-oyl chloride (17.35 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05489570 |
| 出典データセット | uspto-grants-1996_02 |
| ORD ID | ord-6f602d286afe4f3d9c9cd1f5dfbb0e88 |
| 出典メモ | uspto-grants-1996_02 |