反应详情

2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid (15.0 g) was dissolved in 1,2-dichloroethane and N,N-dimethylformamide and thionyl chloride (10.6 g) added. The mixture was heated under reflux for 1 hour, and the solvent evaporated in vacuo. The residue was dissolved in toluene and re-evaporated to yield 2,2-difluoro-1,3-benzodioxol-4-oyl chloride (17.35 g).

1. temperatureThe mixture was heated
2. temperatureunder reflux for 1 hour
3. customthe solvent evaporated in vacuo
4. dissolutionThe residue was dissolved in toluene
5. customre-evaporated