Acetic Anhydride → HCID 53989599, compound

HRID 2395553Notes

Reaction equation

HRID 2395553 reaction equation
[CH:1]1([C:4](=[O:21])[CH2:5][C:6]([C:8]2[CH:18]=[CH:17][C:11]3[S:12][CH:13]=[C:14]([O:15][CH3:16])[C:10]=3[C:9]=2[O:19][CH3:20])=[O:7])[CH2:3][CH2:2]1.[CH:22](OCC)(OCC)[O:23][CH2:24][CH3:25].C(OC(=O)C)(=O)C>C1(C)C=CC=CC=1>[CH:1]1([C:4](=[O:21])[C:5](=[CH:22][O:23][CH2:24][CH3:25])[C:6]([C:8]2[CH:18]=[CH:17][C:11]3[S:12][CH:13]=[C:14]([O:15][CH3:16])[C:10]=3[C:9]=2[O:19][CH3:20])=[O:7])[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 31214Ethyl orthoformateHCID 18989161HCID 18989161, compound

Product 1

HCID 53989599HCID 53989599, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 5-(3-cyclopropyl-1,3-dioxoprop-1-yl)-3,4-dimethoxybenzo[b]thiophene (0.5 g) and triethyl orthoformate (0.73 g) was heated under reflux with acetic anhydride (10 ml) for 3 hours. After cooling and addition of toluene the solution was evaporated to dryness to yield 5-(3-cyclopropyl-2-ethoxymethylene-1,3-dioxoprop-1-yl)-3,4-dimethoxybenzo[b]thiophene as a red oil.

Workup

  1. temperaturewas heated
  2. temperatureAfter cooling
  3. customwas evaporated to dryness

Sources & evidence

ORD record
ord-55d2b7b19e4f43e5a757797d6c2bd339
Source dataset
uspto-grants-1996_02
Patent number
US05489570

Reaction notes

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