Benzoic acid, 4-((5,6,7,8-tetrahydro-5,5-dimethyl-8-oxo-2-naphthalenyl)ethynyl)-, ethyl ester → HCID 17896148, compound

HRID 2395585Notes

Reaction equation

HRID 2395585 reaction equation
CC1(C)C2C=C(C#C[C:14]3[CH:22]=[CH:21][C:17]([C:18]([OH:20])=[O:19])=[CH:16][CH:15]=3)C=CC=2C(=O)CC1.[CH3:25][C:26]1([CH3:50])[C:35]2[CH:34]=[CH:33][C:32]([C:36]#[C:37]C3C=CC(C(OCC)=O)=CC=3)=[CH:31][C:30]=2[C:29](=[O:49])[CH2:28][CH2:27]1>>[CH3:25][C:26]1([CH3:50])[C:35]2[CH:34]=[CH:33][C:32]([C:36]#[C:37][C:16]3[CH:15]=[CH:14][CH:22]=[CH:21][C:17]=3[C:18]([OH:20])=[O:19])=[CH:31][C:30]=2[C:29](=[O:49])[CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 3025901Benzoic acid, 4-((5,6,7,8-tetrahydro-5,5-dimethyl-8-oxo-2-naphthalenyl)ethynyl)-, ethyl ester2×HCID 153455474-((5,6,7,8-Tetrahydro-8,8-dimethyl-5-oxonaphth-2-yl)ethynyl]benzoic acid2×

Product 1

HCID 17896148HCID 17896148, compound

Procedure

Employing the same general procedure as for the preparation of 4- [(5,6,7,8-tetrahydro-8,8-dimethyl-5-oxonaphth-2-yl ) ethynyl]benzoic acid (Compound 7 ) , 500 mg (1.45 mmol) of ethyl 4-[(5,6,7,8 -tetrahydro-8,8-dimethyl-5-oxonaphth-3-yl) ethynyl]benzoate (Compound 2 ) was converted into the title compound using 4 ml (4 mmol) of LiOH (1N aqueous solution).

Sources & evidence

ORD record
ord-a3aef34ac4b6499bac37aa140392b6bf
Source dataset
uspto-grants-1996_02
Patent number
US05489584

Reaction notes

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