Acetonitrile → HCID 15292877, compound

HRID 2395625Notes

Reaction equation

HRID 2395625 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][NH2:9])=[O:7])=[CH:4][CH:3]=1.[CH2:12]([S:14]N=C=O)C.[C:18](#[N:20])[CH3:19]>>[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][NH:9][C:12]([NH:20][CH2:18][CH3:19])=[S:14])=[O:7])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 214504-Aminobenzoic acid hydrazideHCID 21933416HCID 21933416, compound

Product 1

HCID 15292877HCID 15292877, compound

Conditions

Temperature
24 °C

Procedure

A mixture of 4.5 g (29.8 mmol) of 4-aminobenzoic acid hydrazide and 2.6 mL of ethylthioisocyanate in 15 mL of acetonitrile was heated at reflux for 3 hours. The solution was cooled to 24° C., and the precipitate was collected by filtration and dried under vacuum to afford 7.0 g of 1-(4-aminobenzoyl)-4-ethylthiosemicarbazide, mp 113°-115° C.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 3 hours
  3. filtrationthe precipitate was collected by filtration
  4. customdried under vacuum

Sources & evidence

ORD record
ord-754bd0cffe3f4ff7a14ced059730769f
Source dataset
uspto-grants-1996_02
Patent number
US05489598

Reaction notes

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