4-(4-Nitrophenyl)piperidine → 4-(Piperidin-4-yl)aniline

HRID 2395629Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2395629
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-])=O.[H][H]>C(OCC)(=O)C.[Ni]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]2)=[CH:6][CH:5]=1

Komponenten

5

Edukt 2

HCID 159258174-(4-Nitrophenyl)piperidine2×HCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 220478414-(Piperidin-4-yl)anilineAusbeute 74 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A solution of the 4-(4-nitrophenyl) piperidine (29.3 g, 0.144 mol) obtained in (i) in ethyl acetate (150 ml) was hydrogenated at 3 atmospheres over Raney Nickel (5 g) until uptake of hydrogen ceased. Evaporation afforded a brown oil which was crystallised from ether to give the desired product as light yellow crystals (18.5 g, 74% yield), M.pt. 85°-87° C.

Aufarbeitung

  1. customEvaporation
  2. customafforded a brown oil which
  3. customwas crystallised from ether

Quellen und Nachweise

ORD-Eintrag
ord-b5b98ef8a088476ba61b3c6b69275bdb
Quelldatensatz
uspto-grants-1996_02
Patentnummer
US05489599

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