HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Nitrophenyl)piperidine → 4-(Piperidin-4-yl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Nitrophenyl)piperidine | HCID 15925817 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-(Piperidin-4-yl)aniline | HCID 22047841 | 74% |
Reaction Steps
A solution of the 4-(4-nitrophenyl) piperidine (29.3 g, 0.144 mol) obtained in (i) in ethyl acetate (150 ml) was hydrogenated at 3 atmospheres over Raney Nickel (5 g) until uptake of hydrogen ceased. Evaporation afforded a brown oil which was crystallised from ether to give the desired product as light yellow crystals (18.5 g, 74% yield), M.pt. 85°-87° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05489599 |
| Source dataset | uspto-grants-1996_02 |
| ORD ID | ord-b5b98ef8a088476ba61b3c6b69275bdb |
| Source note | uspto-grants-1996_02 |