Pyrrolidine → HCID 136156115, compound

HRID 2395673Notes

Reaction equation

HRID 2395673 reaction equation
CS[C:3](=[NH:8])[NH:4][N+:5]([O-:7])=[O:6].[NH:9]1[CH2:13][CH2:12][CH2:11][CH2:10]1>C(#N)C>[N+:5]([NH:4][C:3]([N:9]1[CH2:13][CH2:12][CH2:11][CH2:10]1)=[NH:8])([O-:7])=[O:6]

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 135927615N-Nitro-S-methylisothiourea

Product 1

HCID 136156115HCID 136156115, compoundYield 93.1%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a mixture of 1.0 g of S-methyl-N-nitroisothiourea and 15 ml of acetonitrile was dropwise added 0.61 g of pyrrolidine within 2 minutes, followed by stirring for 30 minutes. The reaction mixture was concentrated. The resulting precipitate was washed with ethyl ether to afford 1.09 g of 1-(N-nitroamidino)pyrrolidine as white crystals.

Workup

  1. customwithin 2 minutes
  2. concentrationThe reaction mixture was concentrated
  3. washThe resulting precipitate was washed with ethyl ether

Sources & evidence

ORD record
ord-ea7f964fd0874af7899830777c9f13d0
Source dataset
uspto-grants-1996_02
Patent number
US05489603

Reaction notes

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