反应详情

A mixture of 2-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-5-nitropyridine (13.4 g), palladium-carbon (5%, 1.5 g), ethyl acetate (200 ml), and methanol (150 ml) was catalytically reduced at room temperature at 1 atm. After the catalyst was filtered off, the filtrate was concentrated under reduced pressure, and the resulting residual crystal was collected by filtration and recrystallized from ethyl acetate-hexane to yield 5-amino-2-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]pyridine (11.4 g, 93%) as a brown crystal.

1. customwas catalytically reduced at room temperature at 1 atm
2. filtrationAfter the catalyst was filtered off
3. concentrationthe filtrate was concentrated under reduced pressure
4. filtrationthe resulting residual crystal was collected by filtration
5. customrecrystallized from ethyl acetate-hexane