HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2395714Generated: October 30, 2026
Acetic Acid → 1-Oxododecyl-3-hydroxypiperidine
https://huagongshe.com/reaction/2395714
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-oxododecyl-3-(O-tert-butyldimethylsilyoxy)piperidine | HCID 18989546 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-Oxododecyl-3-hydroxypiperidine | HCID 15230342 | — |
Reaction Steps
Mix 1-oxododecyl-3-(O-tert-butyldimethylsilyloxy)piperidine (3.5 mmol) with a solution of acetic acid (9 mL), tetrahydrofuran (6 mL) and water (6 mL). Heat at 75° C. overnight. Cool to room temperature and make basic with cold 10% sodium hydroxide and extract into methylene chloride. Wash with water, then with brine and dry (Na2SO4). Evaporate the solvent in vacuo and purify by flash chromatography (5% methanol/methylene chloride) to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05489600 |
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| Source dataset | uspto-grants-1996_02 |
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| ORD ID | ord-c0d228bc748942b0bd24dc2e018ff071 |
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| Source note | uspto-grants-1996_02 |
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