反应详情

温度

75 °C

Mix 1-oxododecyl-3-(O-tert-butyldimethylsilyloxy)piperidine (3.5 mmol) with a solution of acetic acid (9 mL), tetrahydrofuran (6 mL) and water (6 mL). Heat at 75° C. overnight. Cool to room temperature and make basic with cold 10% sodium hydroxide and extract into methylene chloride. Wash with water, then with brine and dry (Na2SO4). Evaporate the solvent in vacuo and purify by flash chromatography (5% methanol/methylene chloride) to give the title compound.

1. temperatureCool to room temperature
2. extractionextract into methylene chloride
3. washWash with water
4. dry with materialwith brine and dry (Na2SO4)
5. customEvaporate the solvent in vacuo
6. custompurify by flash chromatography (5% methanol/methylene chloride)