Piperazine → HCID 21477614, compound

HRID 2395747Notes

Reaction equation

HRID 2395747 reaction equation
Cl[C:2]1[C:7]([NH:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[N:6][CH:5]=[CH:4][N:3]=1.[NH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>>[CH3:10][C:9]([NH:8][C:7]1[C:2]([N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[N:3][CH:4]=[CH:5][N:6]=1)([CH3:12])[CH3:11]

Participants

3

Reactant 2

HCID 4837PiperazineHCID 21477647HCID 21477647, compound

Product 1

HCID 21477614HCID 21477614, compound

Procedure

Following the general procedure of PREPARATION 25 and making non-critical variations but starting with 2-chloro-3-(1,1-dimethylethylamino)pyrazine (PREPARATION 26, 0.95 g) and piperazine, the title compound is obtained, NMR (CDCl3) 1.47, 1.70, 2.99, 5.02, 7.46 and 7.69 δ.

Workup

  1. customthe general procedure of PREPARATION 25

Sources & evidence

ORD record
ord-969371fd5e5f4b8996786edbb987a7e4
Source dataset
uspto-grants-1996_02
Patent number
US05489593

Reaction notes

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