Potassium Hydroxide → 5H-[1,3]dioxolo[4,5-f]indole-6-carboxylic acid

HRID 2395767Notes

Reaction equation

HRID 2395767 reaction equation
[CH2:1]1[O:12][C:11]2[CH:10]=[C:9]3[C:5]([CH:6]=[C:7]([C:13]([O:15]C)=[O:14])[NH:8]3)=[CH:4][C:3]=2[O:2]1.[OH-].[K+]>>[CH2:1]1[O:12][C:11]2[CH:10]=[C:9]3[C:5]([CH:6]=[C:7]([C:13]([OH:15])=[O:14])[NH:8]3)=[CH:4][C:3]=2[O:2]1

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 10911040Methyl 5H-[1,3]dioxolo[4,5-f]indole-6-carboxylate

Product 1

HCID 9073915H-[1,3]dioxolo[4,5-f]indole-6-carboxylic acid

Procedure

Following the general procedure of PREPARATION 63 and making non-critical variations but starting with methyl 5,6-methylenedioxyindole-2-carboxylate (PREPARATION 78, 4.77 g), potassium hydroxide (1.47 g), the title compound is obtained, C,H,N analysis calcd. for C10H7NO4C, 58.54; H, 3.44; N, 6.83; found: C, 58.27; H, 3.18; N, 6.95.

Workup

  1. customthe general procedure of PREPARATION 63

Sources & evidence

ORD record
ord-472e8c6dc8904fa3a2156bc5970331a0
Source dataset
uspto-grants-1996_02
Patent number
US05489593

Reaction notes

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