Potassium Hydroxide → 5H-[1,3]dioxolo[4,5-f]indole-6-carboxylic acid

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Reaction Steps

Following the general procedure of PREPARATION 63 and making non-critical variations but starting with methyl 5,6-methylenedioxyindole-2-carboxylate (PREPARATION 78, 4.77 g), potassium hydroxide (1.47 g), the title compound is obtained, C,H,N analysis calcd. for C10H7NO4C, 58.54; H, 3.44; N, 6.83; found: C, 58.27; H, 3.18; N, 6.95.

Provenance & Evidence