Hexahydro-1,4-diazepine → HCID 21477605, compound

HRID 2395780Notes

Reaction equation

HRID 2395780 reaction equation
[NH:1]1[CH2:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:9]1[C:14]([NH:15][CH:16]([CH3:18])[CH3:17])=[N:13][CH:12]=[CH:11][N:10]=1>>[CH3:17][CH:16]([NH:15][C:14]1[C:9]([N:1]2[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=[CH:2]2)=[N:10][CH:11]=[CH:12][N:13]=1)[CH3:18]

Participants

3

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 214776373-Chloro-N-(propan-2-yl)pyrazin-2-amine

Product 1

HCID 21477605HCID 21477605, compound

Procedure

Following the general procedure of PREPARATION 24 and making non-critical variations but starting with homopiperazine (2.46 g) and 2-chloro-3-(1-methylethyl)aminopyrazine (PREPARATION 23), the title compound is obtained, NMR (300 MHz, CDCl3) 7.56, 7.34, 4.75, 4.04, 3.28-3.18, 3.00-2.94, 1.79, and 1.15 δ.

Workup

  1. customthe general procedure of PREPARATION 24

Sources & evidence

ORD record
ord-5400d8a8aec842c7b5642e8374c7a5b7
Source dataset
uspto-grants-1996_02
Patent number
US05489593

Reaction notes

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