HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-Carbonyldiimidazole → 1-[5-Benzyloxyindolyl-2-carbonyl]-4-[3-(ethylamino)-2-pyridinyl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 5-(phenylmethoxy)-1H-indole-2-carboxylic acid | HCID 81146 | — |
| Reactant | N-Ethyl-2-(piperazin-1-yl)pyridin-3-amine | HCID 10130476 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-[5-Benzyloxyindolyl-2-carbonyl]-4-[3-(ethylamino)-2-pyridinyl]piperazine | HCID 489428 | — |
Reaction Steps
Following the general procedure of EXAMPLE 16 and making non-critical variations but starting with 5-benzyloxyindole-2-carboxylic acid (1.0 g), 1-(3-ethylamino-2-pyridinyl)piperazine (International Publication WO 87/01706, 0.81 g), 1,1'-carbonyldiimidazole (0.61 g) and THF (7 ml), the title compound is obtained, mp 192°-193°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05489593 |
| Source dataset | uspto-grants-1996_02 |
| ORD ID | ord-e734995ae0b94ae88a018c600fd7a480 |
| Source note | uspto-grants-1996_02 |