1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 1-(3,5-Dimethyl-4-methoxybenzoyl)-4-[3-[(1-methylethyl)amino]-2-pyridinyl]piperazine

HRID 2395795Notes

Reaction equation

HRID 2395795 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([CH3:13])[C:10]=1[O:11][CH3:12])[C:5]([OH:7])=O.[CH3:14][CH:15]([NH:17][C:18]1[C:19]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)=[N:20][CH:21]=[CH:22][CH:23]=1)[CH3:16].C(N=C=NCCCN(C)C)C>>[CH3:13][C:9]1[CH:8]=[C:4]([CH:3]=[C:2]([CH3:1])[C:10]=1[O:11][CH3:12])[C:5]([N:27]1[CH2:28][CH2:29][N:24]([C:19]2[C:18]([NH:17][CH:15]([CH3:16])[CH3:14])=[CH:23][CH:22]=[CH:21][N:20]=2)[CH2:25][CH2:26]1)=[O:7]

Participants

4

Reactant 3

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 889443,5-Dimethyl-p-anisic acidHCID 100137503-Pyridinamine, N-(1-methylethyl)-2-(1-piperazinyl)-

Product 1

HCID 4553761-(3,5-Dimethyl-4-methoxybenzoyl)-4-[3-[(1-methylethyl)amino]-2-pyridinyl]piperazine

Procedure

Following the general procedure of EXAMPLE 16A and making non-critical variations but starting with 3,5-dimethyl-4-methoxybenzoic acid (0.075 g), 1-[3-(1-methylethylamino)-2-pyridinyl]piperazine (0.101 g) and 1-(ethyl)-3-(dimethylaminopropyl)carbodiimide (0.096 g), the title compound is obtained, mp 89°-93°.

Sources & evidence

ORD record
ord-4a91e82a0a3840da84dffd4065209dc0
Source dataset
uspto-grants-1996_02
Patent number
US05489593

Reaction notes

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