1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 1-[6-(N,N-Dimethylamino)indolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piperazine
Reaction equation
[CH3:1][N:2]([C:4]1[CH:12]=[C:11]2[C:7]([CH:8]=[C:9]([C:13]([OH:15])=O)[NH:10]2)=[CH:6][CH:5]=1)[CH3:3].[CH3:16][CH:17]([NH:19][C:20]1[C:21]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[N:22][CH:23]=[CH:24][CH:25]=1)[CH3:18].C(N=C=NCCCN(C)C)C>>[CH3:18][CH:17]([NH:19][C:20]1[CH:25]=[CH:24][CH:23]=[N:22][C:21]=1[N:26]1[CH2:27][CH2:28][N:29]([C:13]([C:9]2[NH:10][C:11]3[CH:12]=[C:4]([N:2]([CH3:1])[CH3:3])[CH:5]=[CH:6][C:7]=3[CH:8]=2)=[O:15])[CH2:30][CH2:31]1)[CH3:16]Participants
4
Reactant 3
Product 1
Procedure
Following the general procedure of EXAMPLE 16A and making non-critical variations but starting with 6-(N,N-dimethylamino)indole-2-carboxylic acid (PREPARATION 89, 0.40 g), 1-[3-(1-methylethylamino)-2-pyridinyl]piperazine (0.43 g) and 1-(ethyl)-3-(dimethylaminopropyl) carbodiimide (0.45 g), the title compound is obtained, mp 153°-154°.
Sources & evidence
- ORD record
- ord-4a49edbfb7f64b38851827e32b22d248
- Source dataset
- uspto-grants-1996_02
- Patent number
- US05489593
Reaction notes
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