反应详情

3,7-Dichloro-8-quinolinecarboxylic acid(20 g, 82 mmol) was added to thionyl chloride(80 ml), and the mixture refluxed for 3 hours and concentrated under reduced pressure to afford the desired product(20.6 g, yield=95.7%) as a light brown solid.

1. temperaturethe mixture refluxed for 3 hours
2. concentrationconcentrated under reduced pressure