Hydrochloric Acid → HCID 18990875, compound

HRID 2395874Notes

Reaction equation

[ClH:1].[C:2]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:15][C:14]([O:16][CH3:17])=[C:13]([C:18]3[CH:23]=[CH:22][C:21]([CH2:24][CH2:25][C:26]([OH:28])=[O:27])=[CH:20][CH:19]=3)[C:12]2=[O:29])=[CH:7][CH:6]=1)(=[NH:4])[NH2:3].[CH:30]1(O)[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1>C(Cl)Cl>[ClH:1].[C:2]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:15][C:14]([O:16][CH3:17])=[C:13]([C:18]3[CH:23]=[CH:22][C:21]([CH2:24][CH2:25][C:26]([O:28][CH:30]4[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]4)=[O:27])=[CH:20][CH:19]=3)[C:12]2=[O:29])=[CH:7][CH:6]=1)(=[NH:3])[NH2:4]

Participants

Conditions

Temperature: 40 °C

Procedure

Prepared by passing dry hydrogen chloride through a solution of 1-(4-amidinophenyl)-3-[4-(2-carboxy-ethyl)phenyl]-4-methoxy-3-pyrrolin-2-one and an excess of cyclohexanol in methylene chloride for one hour and subsequently heating to 40° C. for one hour.

Workup

customPrepared

Sources & evidence

ORD record: ord-baad1ecca7e14fe3a1bde9404d7b4f1f
Source dataset: uspto-grants-1996_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05489693

Reaction notes

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