HCID 10489281, compound → HCID 10773751, compound

HRID 2395955Notes

Reaction equation

HRID 2395955 reaction equation
C([O:4][CH2:5][CH:6]([CH:12]([CH3:14])[CH3:13])[CH2:7][S:8]([NH2:11])(=[O:10])=[O:9])(=O)C.C[O-].[Na+]>CO>[OH:4][CH2:5][CH:6]([CH:12]([CH3:14])[CH3:13])[CH2:7][S:8]([NH2:11])(=[O:9])=[O:10]

Participants

4

Reactant 2

HCID 10489281HCID 10489281, compoundHCID 10942334Sodium Methoxide

Product 1

HCID 10773751HCID 10773751, compoundYield 77.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

7.0 g of 3-acetoxy-2-isopropyl-1-propanesulfonamide was dissolved in 50 ml of methanol. While stirring the solution at room temperature (15° to 20° C.), 6.5 g of 28 w/w % sodium methoxide was added, and reaction was carried out for 30 minutes. The reaction mixture was concentrated to dryness; the residue was then subjected to column chromatography using 100 g of silica gel and eluted with chloroform:methanol (9:1) to yield 4.4 g of the title compound.

Workup

  1. additionwas added
  2. customreaction
  3. concentrationThe reaction mixture was concentrated to dryness
  4. washeluted with chloroform:methanol (9:1)

Sources & evidence

ORD record
ord-0b47213d334748ddbd0e2a2b5b3b528f
Source dataset
uspto-grants-1996_02
Patent number
US05491145

Reaction notes

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