Hydrochloric Acid → HCID 18988118, compound

HRID 2395959Notes

Reaction equation

HRID 2395959 reaction equation
[CH3:1][C:2]1[C:7]([O:8][CH2:9][C:10]([CH3:17])([CH3:16])[CH2:11][S:12](=[O:15])(=[O:14])[NH2:13])=[N:6][N:5]2[CH:18]=[CH:19][N:20]=[C:4]2[C:3]=1[CH3:21].[ClH:22].C(OCC)C>C(O)C>[ClH:22].[CH3:1][C:2]1[C:7]([O:8][CH2:9][C:10]([CH3:17])([CH3:16])[CH2:11][S:12](=[O:14])(=[O:15])[NH2:13])=[N:6][N:5]2[CH:18]=[CH:19][N:20]=[C:4]2[C:3]=1[CH3:21]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 9904880HCID 9904880, compound

Product 1

HCID 18988118HCID 18988118, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.421 g of 7,8-dimethyl-6-(2,2-dimethyl-3-sulfamoyl-1-propoxy)imidazo[1,2-b]pyridazine was suspended in 20 ml of ethanol. To this suspension, 1.65 ml of 1 N hydrochloric acid was added. After the resulting solution was concentratedunder reduced pressure, ethyl ether was added to the residue to cause crystallization, to yield 0.45 g of the title compound.

Workup

  1. additionwas added to the residue
  2. customcrystallization

Sources & evidence

ORD record
ord-5103b87bfab34d7e9b1919f26878b921
Source dataset
uspto-grants-1996_02
Patent number
US05491145

Reaction notes

Loading…