Hydrochloric Acid → 6-(2,2-Dimethyl-3-sulfamoyl-1-propoxy)-7-methylimidazo[1,2-b]pyridazine hydrochloride

HRID 2395961Notes

Reaction equation

HRID 2395961 reaction equation
[CH3:1][C:2]([CH3:20])([CH2:15][S:16](=[O:19])(=[O:18])[NH2:17])[CH2:3][O:4][C:5]1[C:6]([CH3:14])=[CH:7][C:8]2[N:9]([CH:11]=[CH:12][N:13]=2)[N:10]=1.[ClH:21].C(O)C.C(OCC)C>C(O)C>[ClH:21].[CH3:1][C:2]([CH3:20])([CH2:15][S:16](=[O:19])(=[O:18])[NH2:17])[CH2:3][O:4][C:5]1[C:6]([CH3:14])=[CH:7][C:8]2[N:9]([CH:11]=[CH:12][N:13]=2)[N:10]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 108040336-(2,2-Dimethyl-3-sulfamoyl-1-propoxy)-7-methylimidazo[1,2-b]pyridazineHCID 21585056Diethyl ether ethanol

Product 1

HCID 189881376-(2,2-Dimethyl-3-sulfamoyl-1-propoxy)-7-methylimidazo[1,2-b]pyridazine hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.503 g of 6-(2,2-dimethyl-3-sulfamoyl-1-propoxy)-7-methylimidazo[1,2-b]pyridazine was suspended in 15 ml of ethanol. To this suspension, 1.8 ml of 1 N hydrochloric acid was added. After the resulting solution was concentratedunder reduced pressure, ethanol-ethyl ether (4:1) was added to the residue to cause crystallization to yield 0.533 g of the title compound.

Workup

  1. additionwas added to the residue
  2. customcrystallization

Sources & evidence

ORD record
ord-45539dd84cba4bd9aae7da8cb8993d78
Source dataset
uspto-grants-1996_02
Patent number
US05491145

Reaction notes

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