反应详情

0.503 g of 6-(2,2-dimethyl-3-sulfamoyl-1-propoxy)-7-methylimidazo[1,2-b]pyridazine was suspended in 15 ml of ethanol. To this suspension, 1.8 ml of 1 N hydrochloric acid was added. After the resulting solution was concentratedunder reduced pressure, ethanol-ethyl ether (4:1) was added to the residue to cause crystallization to yield 0.533 g of the title compound.

1. additionwas added to the residue
2. customcrystallization