HCID 15656873, compound → HCID 15656881, compound

HRID 2396012Notes

Reaction equation

HRID 2396012 reaction equation
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@H:3]([N:9]1[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][C:15]=3[O:19][CH3:20])[C:10]1=[O:21])[CH2:2]2>O>[N:1]12[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8]1)[C@H:3]([N:9]1[CH2:18][CH2:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][C:15]=3[O:19][CH3:20])[C:10]1=[O:21])[CH2:2]2

Participants

3

Reactant 1

HCID 15656873HCID 15656873, compound

Product 1

HCID 15656881HCID 15656881, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Proceeding as in Example 3, but replacing (S)-2-(1-azabicyclo[2.2.2]oct-3-yl)-5-ethyl-1(2H)-isoquinolinone with (S)-2-(1-azabicyclo[2.2.2]oct-3-yl)-5-methoxy-1(2H)-isoquinolinone, from Example 2, gave (S)-2-(1-azabicyclo[2.2.2]oct-3-yl)-3,4-dihydro-5-methoxy-1(2H)-isoquinolinone, m.p. >290° C. [α]D25 -45.7° (c=0.16 H2O).

Sources & evidence

ORD record
ord-5c3e416dc8f44ceda4d6dc01e90ef09c
Source dataset
uspto-grants-1996_02
Patent number
US05491148

Reaction notes

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