反应详情

Dissolve N-(t-butyloxycarbonyl)-2-(2-propenyl)-β-alanine, methyl ester(5.6 g, 23.0 mmol) in methylene chloride (25 mL) and treat with trifluoroacetic acid (15 mL). Stir for three hours and remove the volatiles in vacuo. Treat the residue with water, make basic with sodium hydroxide (1.0 g, 25 mmol) and extract with ethyl acetate. Separate the organic phase and dry (Na2SO4). Evaporate to give 4.0 g of the title compound as an oil in ethyl acetate.

1. customremove the volatiles in vacuo
2. additionTreat the residue with water
3. extractionextract with ethyl acetate
4. customSeparate the organic phase
5. dry with materialdry (Na2SO4)
6. customEvaporate