Hydrogen Peroxide → HCID 18778850, compound

HRID 2396033Notes

Reaction equation

HRID 2396033 reaction equation
[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([C:15]3[CH:16]=[N:17][C:18]([C:21]#[N:22])=[N:19][CH:20]=3)[CH:10]=[CH:11][C:12]=2[O:13][CH3:14])[CH2:5][CH2:4][CH2:3][CH2:2]1.[OH:23]O.[OH-].[Na+]>C(O)C.O>[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([C:15]3[CH:16]=[N:17][C:18]([C:21]([NH2:22])=[O:23])=[N:19][CH:20]=3)[CH:10]=[CH:11][C:12]=2[O:13][CH3:14])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

6

Reactant 3

HCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 53800255HCID 53800255, compound

Product 1

HCID 18778850HCID 18778850, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a stirred mixture of the compound of Example 14 (1.3 g) in ethanol (8 ml) was added hydrogen peroxide (40 vols, 15 ml) and 6M aqueous NaOH (6 ml). After 15 min, the reaction mixture was diluted with water (75 ml) andthe white solid filtered off. Recrystallisation from acetonitrile furnishedthe title compound (200 g) as small white plates (mp235°-238°C.). Found C, 65.06; H, 6.09; N, 13.44. C17H19N3O3 requires C, 65.16; H, 6.11; N, 13.41%.

Workup

  1. filtrationfiltered off
  2. customRecrystallisation from acetonitrile furnishedthe title compound (200 g) as small white plates (mp235°-238°C.)

Sources & evidence

ORD record
ord-61b8d10637bb45ea87286a712e4f055d
Source dataset
uspto-grants-1996_02
Patent number
US05491147

Reaction notes

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