反应详情

A mixture of [2-(3,5-di-tert-butyl-4-hydroxyphenyl)-5-methyloxazol-4-yl]-acetic acid (2.0 g, 5.8 mmol), N-methoxy-N'-tert-butylcarbodiimide (0.9 g, 5.8 mmol) prepared according to Bull. Chem. Soc. Japan 45, 3607-3611 (1972) and THF (20 mL) was refluxed for 6 hours. The volatiles were removed in vacuo, andthe residue was purified by flash chromatography on acid washed silica gel (5% H3PO4 in MeOH), eluting solvent: hexane/EtOAc 3/1, to give an off-white solid (2.2 g, 94% yield), m.p. 125°-127° C.

1. customprepared
2. customThe volatiles were removed in vacuo
3. customandthe residue was purified by flash chromatography on acid
4. washwashed silica gel (5% H3PO4 in MeOH)
5. washeluting solvent