反应详情

A solution of (2S,3S)-2-t-butoxycarbonylamino-1-cyclohexyl-3-hydroxy-5-methylhexane (120 mg) in trifluoroacetic acid (3 ml) was stirred at 0° C. for 30 minutes. After evaporation of the solvent, the residue was dissolved in ethyl acetate (10 ml). The solution was washed with saturated sodium bicarbonate solution and saturated sodium chloride solution, dried over magnesium sulfate, and evaporated in vacuo to give (2S,3S)-2-amino-1-cyclohexyl-3-hydroxy-5-methylhexane (82 mg) as an oil. Rf: 0.30 (chloroform: methanol: acetic acid, 16:1:1, V/V)

1. customAfter evaporation of the solvent
2. dissolutionthe residue was dissolved in ethyl acetate (10 ml)
3. washThe solution was washed with saturated sodium bicarbonate solution and saturated sodium chloride solution
4. dry with materialdried over magnesium sulfate
5. customevaporated in vacuo