Hydrochloric Acid → HCID 86749254, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of benzyl (2S)-2-[N-[2-(N-t-butoxycarbonyl-N-methylamino)ethyl]-N-methylaminocarbonyl]oxy-3-phenylpropionate (5.40 g) in ethyl acetate (50 ml) which was cooled at 0° C. was added 4N hydrogen chloride solution in ethyl acetate (50 ml). The solution was stirred at 0° C. for 1 hour and the solvent was evaporated in vacuo to give benzyl (2S)-2-[N-[2-(N-methylamino)ethyl]-N-methylaminocarbonyl]oxy-3-phenylpropionate hydrochloride (4.70 g) as a solid. Rf: 0.23 (chloroform:methanol, 10:1, V/V)

Provenance & Evidence