Hydrochloric Acid → HCID 86749254, compound

HRID 2396151Notes

Reaction equation

C(O[C:6]([N:8]([CH2:10][CH2:11][N:12]([CH3:34])[C:13]([O:15][C@@H:16]([CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[C:17]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18])=[O:14])C)=O)(C)(C)C.[ClH:35]>C(OCC)(=O)C>[ClH:35].[CH3:6][NH:8][CH2:10][CH2:11][N:12]([CH3:34])[C:13]([O:15][C@@H:16]([CH2:27][C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)[C:17]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18])=[O:14]

Participants

Conditions

Temperature: 0 °C

Procedure

To a solution of benzyl (2S)-2-[N-[2-(N-t-butoxycarbonyl-N-methylamino)ethyl]-N-methylaminocarbonyl]oxy-3-phenylpropionate (5.40 g) in ethyl acetate (50 ml) which was cooled at 0° C. was added 4N hydrogen chloride solution in ethyl acetate (50 ml). The solution was stirred at 0° C. for 1 hour and the solvent was evaporated in vacuo to give benzyl (2S)-2-[N-[2-(N-methylamino)ethyl]-N-methylaminocarbonyl]oxy-3-phenylpropionate hydrochloride (4.70 g) as a solid. Rf: 0.23 (chloroform:methanol, 10:1, V/V)

Workup

customthe solvent was evaporated in vacuo

Sources & evidence

ORD record: ord-5a79e2b1732f4de2be2cac0df48e6994
Source dataset: uspto-grants-1996_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05491132

Reaction notes

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