Hydrochloric Acid → HCID 178444647, compound

Participants

Reaction Steps

To a solution of (2S,3S)-2-[Nα -[N-[N-methyl-N-{2-(N-thiomorpholinocarbonyl-N-methylamino)ethyl}aminocarbonyl]-L-phenylalanyl]-Nα -methyl-L-histidyl]amino-1-cyclohexyl-3-hydroxy-6-methylheptane (300 mg) in ethanol (3 ml), which was cooled to 0° C., was added a solution of 4M hydrogen chloride in ethyl acetate (0.100 ml). After being stirred at the same temperature for 10 minutes, the solution was concentrated in vacuo to give (2S,3S)-2-[Nα -[N-[N-methyl-{2-(N-thiomorpholinocarbonyl-N-methylamino)ethyl}aminocarbonyl]-L-phenylalanyl]-Nα -methyl-L-histidyl]amino-1-cyclohexyl-3-hydroxy-6-methylheptane hydrochloride (310 mg) as an amorphous powder. Rf: 0.38 (10% methanol in chloroform)

Provenance & Evidence