Hydrochloric Acid → HCID 178444647, compound

HRID 2396154Notes

Reaction equation

HRID 2396154 reaction equation
[CH3:1][N:2]([CH2:43][CH2:44][N:45]([C:47]([N:49]1[CH2:54][CH2:53][S:52][CH2:51][CH2:50]1)=[O:48])[CH3:46])[C:3]([NH:5][C@H:6]([C:14]([N:16]([CH3:42])[C@H:17]([C:24]([NH:26][C@H:27]([C@@H:35]([OH:41])[CH2:36][CH2:37][CH:38]([CH3:40])[CH3:39])[CH2:28][CH:29]1[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]1)=[O:25])[CH2:18][C:19]1[N:23]=[CH:22][NH:21][CH:20]=1)=[O:15])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:4].[ClH:55]>C(O)C.C(OCC)(=O)C>[ClH:55].[CH3:1][N:2]([CH2:43][CH2:44][N:45]([C:47]([N:49]1[CH2:54][CH2:53][S:52][CH2:51][CH2:50]1)=[O:48])[CH3:46])[C:3]([NH:5][C@H:6]([C:14]([N:16]([CH3:42])[C@H:17]([C:24]([NH:26][C@H:27]([C@@H:35]([OH:41])[CH2:36][CH2:37][CH:38]([CH3:40])[CH3:39])[CH2:28][CH:29]1[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]1)=[O:25])[CH2:18][C:19]1[N:23]=[CH:22][NH:21][CH:20]=1)=[O:15])[CH2:7][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)=[O:4]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178444646HCID 178444646, compound

Product 1

HCID 178444647HCID 178444647, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of (2S,3S)-2-[Nα -[N-[N-methyl-N-{2-(N-thiomorpholinocarbonyl-N-methylamino)ethyl}aminocarbonyl]-L-phenylalanyl]-Nα -methyl-L-histidyl]amino-1-cyclohexyl-3-hydroxy-6-methylheptane (300 mg) in ethanol (3 ml), which was cooled to 0° C., was added a solution of 4M hydrogen chloride in ethyl acetate (0.100 ml). After being stirred at the same temperature for 10 minutes, the solution was concentrated in vacuo to give (2S,3S)-2-[Nα -[N-[N-methyl-{2-(N-thiomorpholinocarbonyl-N-methylamino)ethyl}aminocarbonyl]-L-phenylalanyl]-Nα -methyl-L-histidyl]amino-1-cyclohexyl-3-hydroxy-6-methylheptane hydrochloride (310 mg) as an amorphous powder. Rf: 0.38 (10% methanol in chloroform)

Workup

  1. concentrationthe solution was concentrated in vacuo

Sources & evidence

ORD record
ord-c41d1f89eef140378d75b189ca7d116f
Source dataset
uspto-grants-1996_02
Patent number
US05491132

Reaction notes

Loading…