Hydrochloric Acid → HCID 178446063, compound

Participants

Reaction Steps

To a solution of (2S,3S)-2-[Nα -[N-[N-methyl-N-{2-(N-morpholinocarbonyl-N-methylamino)ethyl}aminocarbonyl]-L-phenylalanyl]-Nα -methyl-L-histidyl]amino-1-cyclohexyl-3-hydroxy-5-methylhexane (210 mg) inethanol (10 ml), which was cooled to 0° C., was added a solution of 4M hydrogen chloride in ethyl acetate (71 μl). After being stirred at the same temperature for 5 minutes, the solution was concentrated under reduced pressure to give (2S,3S)-2-[Nα -[N-[N-methyl-N-{2-(N-morpholinocarbonyl-N-methylamino)ethyl}aminocarbonyl]-L-phenylalanyl]-Nα -methyl-L-histidyl]amino-1-cyclohexyl-3-hydroxy-5-methylhexane hydrochloride (216 mg) as an amorphous powder. Rf: 0.33 (10% methanol in chloroform)

Provenance & Evidence