Hydrochloric Acid → HCID 178446063, compound

HRID 2396155Notes

Reaction equation

HRID 2396155 reaction equation
[CH3:1][N:2]([CH2:42][CH2:43][N:44]([C:46]([N:48]1[CH2:53][CH2:52][O:51][CH2:50][CH2:49]1)=[O:47])[CH3:45])[C:3]([NH:5][C@H:6]([C:14]([N:16]([CH3:41])[C@H:17]([C:24]([NH:26][C@H:27]([C@@H:35]([OH:40])[CH2:36][CH:37]([CH3:39])[CH3:38])[CH2:28][CH:29]1[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]1)=[O:25])[CH2:18][C:19]1[N:23]=[CH:22][NH:21][CH:20]=1)=[O:15])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:4].[ClH:54]>C(OCC)(=O)C>[ClH:54].[CH3:1][N:2]([CH2:42][CH2:43][N:44]([C:46]([N:48]1[CH2:49][CH2:50][O:51][CH2:52][CH2:53]1)=[O:47])[CH3:45])[C:3]([NH:5][C@H:6]([C:14]([N:16]([CH3:41])[C@H:17]([C:24]([NH:26][C@H:27]([C@@H:35]([OH:40])[CH2:36][CH:37]([CH3:39])[CH3:38])[CH2:28][CH:29]1[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]1)=[O:25])[CH2:18][C:19]1[N:23]=[CH:22][NH:21][CH:20]=1)=[O:15])[CH2:7][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178446062HCID 178446062, compound

Product 1

HCID 178446063HCID 178446063, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of (2S,3S)-2-[Nα -[N-[N-methyl-N-{2-(N-morpholinocarbonyl-N-methylamino)ethyl}aminocarbonyl]-L-phenylalanyl]-Nα -methyl-L-histidyl]amino-1-cyclohexyl-3-hydroxy-5-methylhexane (210 mg) inethanol (10 ml), which was cooled to 0° C., was added a solution of 4M hydrogen chloride in ethyl acetate (71 μl). After being stirred at the same temperature for 5 minutes, the solution was concentrated under reduced pressure to give (2S,3S)-2-[Nα -[N-[N-methyl-N-{2-(N-morpholinocarbonyl-N-methylamino)ethyl}aminocarbonyl]-L-phenylalanyl]-Nα -methyl-L-histidyl]amino-1-cyclohexyl-3-hydroxy-5-methylhexane hydrochloride (216 mg) as an amorphous powder. Rf: 0.33 (10% methanol in chloroform)

Workup

  1. concentrationthe solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-1248fa22401f4253b18afd9fd7808aa9
Source dataset
uspto-grants-1996_02
Patent number
US05491132

Reaction notes

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