Hydrochloric Acid → 5-(3,4-Dimethoxybenzyl)uracil

HRID 2396303Notes

Reaction equation

HRID 2396303 reaction equation
O[CH2:2][C:3]1[C:4](=[O:10])[NH:5][C:6](=[O:9])[NH:7][CH:8]=1.Cl.[C:12]1([O:20][CH3:21])[C:13](=[CH:16][CH:17]=[CH:18][CH:19]=1)[O:14][CH3:15]>>[CH3:15][O:14][C:13]1[CH:16]=[C:17]([CH:18]=[CH:19][C:12]=1[O:20][CH3:21])[CH2:2][C:3]1[C:4](=[O:10])[NH:5][C:6](=[O:9])[NH:7][CH:8]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 7043VeratroleHCID 781685-(Hydroxymethyl)uracil

Product 1

HCID 103553285-(3,4-Dimethoxybenzyl)uracil

Procedure

A solution of 5.0 g of 5-hydroxymethyluracil, 150 ml of veratrole and 0.5 ml of concentrated hydrochloric acid was heated at 140° C. for one hour. The precipitate was filtered, washed with ether and recrystallized from hot methanol, 6.85 g, M+ 263.20.

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed with ether
  3. customrecrystallized from hot methanol, 6.85 g, M+ 263.20

Sources & evidence

ORD record
ord-1b96aafba8074542a8354153b2d9f0a6
Source dataset
uspto-grants-1996_02
Patent number
US05491234

Reaction notes

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