1-Bromo-2,4-dichloro-5-fluorobenzene → 2,4-Dichloro-5-fluorobenzonitrile

HRID 2396434Notes

Reaction equation

HRID 2396434 reaction equation
Br[C:2]1[C:3]([Cl:10])=[CH:4][C:5]([Cl:9])=[C:6]([F:8])[CH:7]=1.[Cu][C:12]#[N:13]>>[Cl:10][C:3]1[CH:4]=[C:5]([Cl:9])[C:6]([F:8])=[CH:7][C:2]=1[C:12]#[N:13]

Participants

3

Reactant 2

HCID 117913931-Bromo-2,4-dichloro-5-fluorobenzeneHCID 178418546HCID 178418546, compound

Product 1

HCID 27827532,4-Dichloro-5-fluorobenzonitrile

Conditions

Temperature
150 °C

Procedure

48.8 g (0.2 mol) of 5-bromo-2,4-dichlorofluorobenzene and 17.9 g (0.2 mol) of copper(I) cyanide were introduced into a 100 ml 3-neck flask fitted with a reflux condenser and blade stirrer and stirred at 150° C. for 4 hours (no reaction). The reaction suspension was heated to 200° C. and stirred for a further 4 hours at this temperature: no reaction, 0 GC area-%.

Workup

  1. customfitted with a reflux condenser and blade stirrer
  2. customno reaction)
  3. temperatureThe reaction suspension was heated to 200° C.
  4. stirringstirred for a further 4 hours at this temperature
  5. customno reaction, 0 GC area-%

Sources & evidence

ORD record
ord-3a9b3c4e47e34db0898e9ae91c650d77
Source dataset
uspto-grants-1996_02
Patent number
US05492875

Reaction notes

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