1-Bromo-2,4-dichloro-5-fluorobenzene → 2,4-Dichloro-5-fluorobenzonitrile

Participants

Reaction Conditions

Reaction Steps

48.8 g (0.2 mol) of 5-bromo-2,4-dichlorofluorobenzene and 17.9 g (0.2 mol) of copper(I) cyanide were introduced into a 100 ml 3-neck flask fitted with a reflux condenser and blade stirrer and stirred at 150° C. for 4 hours (no reaction). The reaction suspension was heated to 200° C. and stirred for a further 4 hours at this temperature: no reaction, 0 GC area-%.

Provenance & Evidence