2,3-Dichloronitrobenzene → 1-Chloro-2-fluoro-3-nitrobenzene

HRID 2396436Notes

Reaction equation

HRID 2396436 reaction equation
Cl[C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[F-:12].[K+]>>[Cl:8][C:7]1[C:2]([F:12])=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 185552,3-DichloronitrobenzeneHCID 522689Potassium Fluoride

Product 1

HCID 750161-Chloro-2-fluoro-3-nitrobenzene

Conditions

Temperature
150 °C

Procedure

57.6 g (0.3 mol) of 2,3-dichloronitrobenzene and 13.9 g (0.24 mol) of potassium fluoride were introduced into a 100 ml flange flask and fitted with a reflux condenser and blade stirrer and stirred at 150° C. for 2 hours (no reaction). The reaction suspension was heated to 190° C. and stirred for a further 4 hours at this temperature. Amount of 3-chloro-2-fluoronitrobenzene formed: after 2 hours: 1 GC area-%. after 8 hours: 8 GC area-%.

Workup

  1. customfitted with a reflux condenser and blade stirrer
  2. customno reaction)
  3. temperatureThe reaction suspension was heated to 190° C.
  4. stirringstirred for a further 4 hours at this temperature

Sources & evidence

ORD record
ord-0cc75ef7f21848378dc6ee0b70959b11
Source dataset
uspto-grants-1996_02
Patent number
US05492875

Reaction notes

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