Sodium ethoxide → HCID 18987348, compound

HRID 2396519Notes

Reaction equation

HRID 2396519 reaction equation
[C:1]([NH:4][C:5]1[CH:17]=[CH:16][CH:15]=[CH:14][C:6]=1[C:7]([C:9]1[S:10][CH:11]=[CH:12][CH:13]=1)=O)(=[O:3])[CH3:2].CC[O-].[Na+]>C(O)C.O>[S:10]1[CH:11]=[CH:12][CH:13]=[C:9]1[C:7]1[C:6]2[C:5](=[CH:17][CH:16]=[CH:15][CH:14]=2)[NH:4][C:1](=[O:3])[CH:2]=1

Participants

5

Reactant 2

HCID 2723922Sodium ethoxide2×HCID 18987253HCID 18987253, compound

Product 1

HCID 18987348HCID 18987348, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of 2-(2-acetylaminobenzoyl)thiophene (4.8 g) in ethanol (60 cc) is added sodium ethylate (3.2 g). The reaction mixture is refluxed for 9 hours, treated again with sodium ethylate (0.5 g) and then allowed to reflux for 10 hours. The mixture is poured in iced water (200 cc). The precipitate formed is filtered, washed with distilled water until neutrality and then with acetone (3×50 cc) and dried at 40° C. under reduced pressure. The residue thus obtained is recrystallized in ethanol to obtain the product as a yellow solid. (m.p.=262°-264° C.)

Workup

  1. temperatureThe reaction mixture is refluxed for 9 hours
  2. temperatureto reflux for 10 hours
  3. customThe precipitate formed
  4. filtrationis filtered
  5. washwashed with distilled water until neutrality
  6. dry with materialwith acetone (3×50 cc) and dried at 40° C. under reduced pressure
  7. customThe residue thus obtained
  8. customis recrystallized in ethanol

Sources & evidence

ORD record
ord-23a139d57000490f8f4a6855e4d65dcb
Source dataset
uspto-grants-1996_02
Patent number
US05492915

Reaction notes

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