o-(Trifluoromethyl)benzaldehyde → HCID 18987466, compound

HRID 2396562Notes

Reaction equation

HRID 2396562 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([C:9](=O)[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[C:16]([F:19])([F:18])[F:17])[CH:3]=1.BrC1C=C(Cl)C=CC=1OCO[CH2:32][CH2:33][O:34]C.FC(F)(F)C1C=CC=CC=1C=[O:41]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]2[O:8][C:32]([C:33]([OH:34])=[O:41])=[C:9]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[C:16]([F:19])([F:18])[F:17])[C:4]=2[CH:3]=1

Participants

4

Reactant 3

HCID 123067o-(Trifluoromethyl)benzaldehydeHCID 21463257HCID 21463257, compoundHCID 21463259HCID 21463259, compound

Product 1

HCID 18987466HCID 18987466, compound

Procedure

Using 4-chloro-2-(2-trifluoromethylbenzoyl)phenol [prepared from 2-bromo-4-chloro-(2methoxyethoxy)methoxybenzene and ortho(trifluoromethyl)benzaldehyde as the starting materials: m.p. 71°-72° C. (recrystallized from hexaneisopropyl ether)] in place of 4-chloro-2-benzoylphenol in Reference Example 1, substantially the same reactions as in Step 1 to Step 3 of Reference Example 1 were conducted to give the title compound. The compounds obtained in the respective steps and their physicochemical data are shown below.

Workup

  1. customm.p. 71°-72° C. (recrystallized from hexaneisopropyl ether)] in place of 4-chloro-2-benzoylphenol in Reference Example 1

Sources & evidence

ORD record
ord-a7c08495ae6149d19c1f8aacdb90314f
Source dataset
uspto-grants-1996_02
Patent number
US05492929

Reaction notes

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