N,N-Dimethylaniline → 4-Chloro-2-(methylthio)thieno[3,2-d]pyrimidine

4-Hydroxy-2-methylthiothiopheno[3,2-d ]pyrimidine (15.4 g, 78 mmol) was combined with 50 mL of dry acetonitrile and 29 mL (312 mmol) of phosphoryl chloride and 10 mL (78 mmol) of N,N-dimethylaniline were added with stirring. The mixture was heated to reflux with stirring for 2 hours. It was then allowed to cool and most of the acetonitrile was removed by evaporation under reduced pressure. The residue was poured slowly into 200 mL of cold water with cooling and agitation. The resulting mixture was extracted with 4×500 mL of ether and the combined ethereal extracts were dried over magnesium sulfate and concentrated by evaporation under reduced pressure. The 15.3 g of tan solid title compound obtained melted at 115°-118° C. and had a proton NMR spectrum consistent with the assigned structure.

1. additionwere added
2. temperatureThe mixture was heated
3. temperatureto reflux
4. stirringwith stirring for 2 hours
5. customwas removed by evaporation under reduced pressure
6. additionThe residue was poured slowly into 200 mL of cold water
7. temperaturewith cooling
8. extractionThe resulting mixture was extracted with 4×500 mL of ether
9. dry with materialthe combined ethereal extracts were dried over magnesium sulfate
10. concentrationconcentrated by evaporation under reduced pressure

ORD record

ord-477fb405113643878e9c2857e4d8c139

Source dataset

uspto-grants-1996_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05494887