反应详情

温度

120 °C

To a mixture of 4-propyl-1,2,5-thiadiazolidin-3-one 1,1dioxide (1.0 g, 5.6 mmol) suspended in 15 ml of toluene containing tetrabutylammonium bromide (0.18 g, 0.56 mmol) was added phenylthiomethyl chloride (0.98 g, 6.2 mmol) and the resulting mixture was refluxed (120° C.) for 20 hours. The mixture was cooled, filtered, and the filtrate was concentrated in vacuo. The residue was purified by silica gel flash column chromatography (20% of ethyl acetate in hexane) to afford 1.16 g of 2-phenylthiomethyl-4-propyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide (Formula VI: R1 =H; R2 =propyl; R3 =H).

1. temperatureThe mixture was cooled
2. filtrationfiltered
3. concentrationthe filtrate was concentrated in vacuo
4. customThe residue was purified by silica gel flash column chromatography (20% of ethyl acetate in hexane)